Cellular / Molecular Neuroligin 1 Is Dynamically Exchanged at Postsynaptic Sites
نویسندگان
چکیده
Inga U. Schapitz,1* Bardo Behrend,1* Yvonne Pechmann,1 Corinna Lappe-Siefke,1 Silas J. Kneussel,1 Karen E. Wallace,3 A. Vanessa Stempel,5 Fritz Buck,2 Seth G. N. Grant,4 Michaela Schweizer,1 Dietmar Schmitz,5 Jürgen R. Schwarz,1 Erika L. F. Holzbaur,3 and Matthias Kneussel1 1Center for Molecular Neurobiology (ZMNH), University of Hamburg Medical School, D-20251 Hamburg, Germany, 2Institute of Clinical Chemistry, University of Hamburg Medical School, D-20246 Hamburg, Germany, 3Department of Physiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, 4Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom, and 5Neuroscience Research Center of the Charité, Universitätsmedizin Berlin, D-10117 Berlin, Germany
منابع مشابه
Neuroligin 1 is dynamically exchanged at postsynaptic sites.
Neuroligins are postsynaptic cell adhesion molecules that associate with presynaptic neurexins. Both factors form a transsynaptic connection, mediate signaling across the synapse, specify synaptic functions, and play a role in synapse formation. Neuroligin dysfunction impairs synaptic transmission, disrupts neuronal networks, and is thought to participate in cognitive diseases. Here we report t...
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